270766

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 879090..879715 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag PQQ15_RS04330 Protein ID WP_000911336.1
Coordinates 879317..879715 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PQQ15_RS04325 Protein ID WP_000557549.1
Coordinates 879090..879317 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS04295 (874135) 874135..875652 + 1518 WP_023171334.1 lysine--tRNA ligase -
PQQ15_RS04300 (875728) 875728..876273 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PQQ15_RS04305 (876538) 876538..877296 + 759 WP_000244329.1 amidase activator ActS -
PQQ15_RS04315 (877581) 877581..878387 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PQQ15_RS04320 (878662) 878662..878913 - 252 WP_001540858.1 hypothetical protein -
PQQ15_RS04325 (879090) 879090..879317 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQQ15_RS04330 (879317) 879317..879715 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQQ15_RS04335 (880521) 880521..881057 + 537 WP_001038506.1 STM3031 family outer membrane protein -
PQQ15_RS04340 (881104) 881104..881736 + 633 WP_000835265.1 YfdX family protein -
PQQ15_RS04345 (882455) 882455..883039 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 877581..888906 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T270766 WP_000911336.1 NZ_CP117357:879317-879715 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT270766 WP_000557549.1 NZ_CP117357:879090-879317 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References