221687

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3573510..3574135 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF46_RS17485 Protein ID WP_000911336.1
Coordinates 3573510..3573908 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF46_RS17490 Protein ID WP_000557549.1
Coordinates 3573908..3574135 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS17470 (3570187) 3570187..3570768 - 582 WP_001244651.1 fimbrial protein -
LJF46_RS17475 (3571487) 3571487..3572119 - 633 WP_000835265.1 YfdX family protein -
LJF46_RS17480 (3572166) 3572166..3572702 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF46_RS17485 (3573510) 3573510..3573908 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF46_RS17490 (3573908) 3573908..3574135 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF46_RS17495 (3574344) 3574344..3574595 + 252 WP_001576352.1 hypothetical protein -
LJF46_RS17500 (3574875) 3574875..3575681 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF46_RS17510 (3575966) 3575966..3576724 - 759 WP_000244328.1 amidase activator ActS -
LJF46_RS17515 (3576989) 3576989..3577534 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF46_RS17520 (3577610) 3577610..3579127 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3565071..3575681 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-123)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221687 WP_000911336.1 NZ_CP085806:c3573908-3573510 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221687 NZ_CP117568:2299537-2300001 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTTTCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACAGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221687 WP_000557549.1 NZ_CP085806:c3574135-3573908 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221687 NZ_CP117568:2299202-2299537 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM


Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References