Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 843799..844424 Replicon chromosome
Accession NZ_CP102669
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NUW86_RS04080 Protein ID WP_000911336.1
Coordinates 844026..844424 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NUW86_RS04075 Protein ID WP_000557549.1
Coordinates 843799..844026 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW86_RS04045 (838844) 838844..840361 + 1518 WP_000003339.1 lysine--tRNA ligase -
NUW86_RS04050 (840437) 840437..840982 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NUW86_RS04055 (841247) 841247..842005 + 759 WP_000244329.1 amidase activator ActS -
NUW86_RS04065 (842290) 842290..843096 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NUW86_RS04070 (843371) 843371..843622 - 252 WP_001540858.1 hypothetical protein -
NUW86_RS04075 (843799) 843799..844026 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NUW86_RS04080 (844026) 844026..844424 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NUW86_RS04085 (845230) 845230..845766 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NUW86_RS04090 (845813) 845813..846445 + 633 WP_000835265.1 YfdX family protein -
NUW86_RS04095 (847164) 847164..847748 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 842290..853615 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T253911 WP_000911336.1 NZ_CP102669:844026-844424 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT253911 WP_000557549.1 NZ_CP102669:843799-844026 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References