Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4313601..4314226 Replicon chromosome
Accession NZ_CP085796
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Froakie

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF57_RS20925 Protein ID WP_000911336.1
Coordinates 4313601..4313999 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF57_RS20930 Protein ID WP_000557549.1
Coordinates 4313999..4314226 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF57_RS20910 (4310278) 4310278..4310859 - 582 WP_001244651.1 fimbrial protein -
LJF57_RS20915 (4311578) 4311578..4312210 - 633 WP_000835265.1 YfdX family protein -
LJF57_RS20920 (4312257) 4312257..4312793 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF57_RS20925 (4313601) 4313601..4313999 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF57_RS20930 (4313999) 4313999..4314226 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF57_RS20935 (4314435) 4314435..4314686 + 252 WP_001576352.1 hypothetical protein -
LJF57_RS20940 (4314966) 4314966..4315772 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF57_RS20950 (4316057) 4316057..4316815 - 759 WP_000244328.1 amidase activator ActS -
LJF57_RS20955 (4317080) 4317080..4317625 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF57_RS20960 (4317701) 4317701..4319218 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4305162..4315772 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221432 WP_000911336.1 NZ_CP085796:c4313999-4313601 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221432 NZ_CP117392:1961070-1961173 [Salmonella enterica subsp. enterica serovar Give]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221432 WP_000557549.1 NZ_CP085796:c4314226-4313999 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221432 NZ_CP117392:c1961175-1961032 [Salmonella enterica subsp. enterica serovar Give]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References