Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4037424..4038049 Replicon chromosome
Accession NZ_CP060678
Organism Salmonella enterica strain 190610_1

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag H9Q82_RS19605 Protein ID WP_000911336.1
Coordinates 4037424..4037822 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag H9Q82_RS19610 Protein ID WP_000557549.1
Coordinates 4037822..4038049 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q82_RS19590 (4034101) 4034101..4034682 - 582 WP_001244651.1 fimbrial protein -
H9Q82_RS19595 (4035401) 4035401..4036033 - 633 WP_000835265.1 YfdX family protein -
H9Q82_RS19600 (4036080) 4036080..4036616 - 537 WP_001038502.1 STM3031 family outer membrane protein -
H9Q82_RS19605 (4037424) 4037424..4037822 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
H9Q82_RS19610 (4037822) 4037822..4038049 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9Q82_RS19615 (4038258) 4038258..4038509 + 252 WP_001576352.1 hypothetical protein -
H9Q82_RS19620 (4038789) 4038789..4039595 + 807 WP_001574939.1 DUF1460 domain-containing protein -
H9Q82_RS19630 (4039880) 4039880..4040638 - 759 WP_000244328.1 amidase activator ActS -
H9Q82_RS19635 (4040903) 4040903..4041448 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
H9Q82_RS19640 (4041524) 4041524..4043041 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4028985..4039595 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T170726 WP_000911336.1 NZ_CP060678:c4037822-4037424 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T170726 NZ_CP077691:c4289541-4289203 [Salmonella enterica subsp. enterica]
ATGAAAATCCTTTCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCTGTACTTGTCTGGCAAACGCTACTGACACG
CCTGCTGGAGCAACACTATGGCCTGTCGCTGAACGATACGCCGTTCAGTGATGAAACGGTTATTCAGGAGCATATCAACG
CCGGTATCACGCTGGCGGATGCAGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTTAAC
TGTCAGGAACAGTCGCCTTACCTTCGGGCGGTTGATATTTTACGGGCGCGACAGGCTACTGGTCTGTTGCGGCAAAACCA
GCTTCCTTCGACACGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT170726 WP_000557549.1 NZ_CP060678:c4038049-4037822 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT170726 NZ_CP077691:c4289895-4289566 [Salmonella enterica subsp. enterica]
ATGGATAAAGAAACCGACACAGTACAGTGGGGACTCAACCGACCTGGTTCTCCTCAATTTAGCGCACGCCTGGTACAAGA
AGGCAAACGCCTACATTATTTAGCTGACCGCGCCGGGATAACAGGCGCTTTCAATGAAGAAGAGTGTCACCAACTGAATG
CCGCATTTCCGCACTTCGTAAAACAAATGGAGCTGATGCTGCTCTCTGGTGAGCTTAACCCCCGCCATGCATATCGCGTA
ACGCTGTACCACAACGAACTGACCTGTGAAGCAGATACGCTCGGTAGCTGTGGCTACGTTTATATAGCGATTTATCCCAC
TCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References