146346

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4059367..4059992 Replicon chromosome
Accession NZ_CP047522
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN15_RS19800 Protein ID WP_000911336.1
Coordinates 4059367..4059765 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN15_RS19805 Protein ID WP_000557549.1
Coordinates 4059765..4059992 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN15_RS19785 (4056043) 4056043..4056627 - 585 WP_001244638.1 fimbrial protein -
DXN15_RS19790 (4057346) 4057346..4057978 - 633 WP_000835265.1 YfdX family protein -
DXN15_RS19795 (4058025) 4058025..4058561 - 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN15_RS19800 (4059367) 4059367..4059765 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN15_RS19805 (4059765) 4059765..4059992 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN15_RS19810 (4060169) 4060169..4060420 + 252 WP_001540858.1 hypothetical protein -
DXN15_RS19815 (4060695) 4060695..4061501 + 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN15_RS19825 (4061786) 4061786..4062544 - 759 WP_000244329.1 amidase activator ActS -
DXN15_RS19830 (4062809) 4062809..4063354 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN15_RS19835 (4063430) 4063430..4064947 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4050921..4061501 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146346 WP_000911336.1 NZ_CP047522:c4059765-4059367 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146346 NZ_CP062742:3111764-3111871 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146346 WP_000557549.1 NZ_CP047522:c4059992-4059765 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146346 NZ_CP062742:c3111716-3111657 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References