Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4345817..4346442 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF67_RS21165 Protein ID WP_000911336.1
Coordinates 4345817..4346215 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF67_RS21170 Protein ID WP_000557549.1
Coordinates 4346215..4346442 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS21150 (4342494) 4342494..4343075 - 582 WP_001244651.1 fimbrial protein -
LJF67_RS21155 (4343794) 4343794..4344426 - 633 WP_000835265.1 YfdX family protein -
LJF67_RS21160 (4344473) 4344473..4345009 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF67_RS21165 (4345817) 4345817..4346215 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF67_RS21170 (4346215) 4346215..4346442 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF67_RS21175 (4346651) 4346651..4346902 + 252 WP_001576352.1 hypothetical protein -
LJF67_RS21180 (4347182) 4347182..4347988 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF67_RS21190 (4348273) 4348273..4349031 - 759 WP_000244328.1 amidase activator ActS -
LJF67_RS21195 (4349296) 4349296..4349841 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF67_RS21200 (4349917) 4349917..4351434 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4337378..4347988 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221928 WP_000911336.1 NZ_CP085817:c4346215-4345817 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221928 NZ_CP117630:c57420-57040 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221928 WP_000557549.1 NZ_CP085817:c4346442-4346215 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221928 NZ_CP117630:c57641-57420 [Escherichia albertii]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References