231071

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1046857..1047482 Replicon chromosome
Accession NZ_CP090535
Organism Salmonella enterica strain 2016089-SE

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag L0F58_RS05065 Protein ID WP_000911336.1
Coordinates 1046857..1047255 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag L0F58_RS05070 Protein ID WP_000557549.1
Coordinates 1047255..1047482 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F58_RS05050 (1043533) 1043533..1044117 - 585 WP_001244638.1 fimbrial protein -
L0F58_RS05055 (1044836) 1044836..1045468 - 633 WP_000835265.1 YfdX family protein -
L0F58_RS05060 (1045515) 1045515..1046051 - 537 WP_001038506.1 STM3031 family outer membrane protein -
L0F58_RS05065 (1046857) 1046857..1047255 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
L0F58_RS05070 (1047255) 1047255..1047482 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
L0F58_RS05075 (1047659) 1047659..1047910 + 252 WP_001540858.1 hypothetical protein -
L0F58_RS05080 (1048185) 1048185..1048991 + 807 WP_010989071.1 DUF1460 domain-containing protein -
L0F58_RS05090 (1049276) 1049276..1050034 - 759 WP_000244329.1 amidase activator ActS -
L0F58_RS05095 (1050299) 1050299..1050844 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
L0F58_RS05100 (1050920) 1050920..1052437 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1038411..1048991 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T231071 WP_000911336.1 NZ_CP090535:c1047255-1046857 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T231071 NZ_CP125946:c468839-468585 [Rothia sp. SD9660Na]
ATGAAAACTATGACCTACACCGAGTCCCGCGCCAATTACGCCCAAGTACTCGATATCGCTGTAGAAGACCTTGAAGAGGT
TGTGATTACCCGTACAGGGCGCGAACCTGCCGTCATTCTTTCGCTTGCCGAATACGAATCACTCAAAGAGACCGCTCATC
TCTTACGTTCGCCTGCCAATGCTCGAAGGCTGTTAGATTCAATTGACGAACTTGAAGCAAGCGGAGGATCCAGCCAGGCA
CTCCTCGAAGATTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT231071 WP_000557549.1 NZ_CP090535:c1047482-1047255 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT231071 NZ_CP125946:c468576-468319 [Rothia sp. SD9660Na]
GTGGAACTTATCTGGAGCAGTCAGGCCTGGGAAGACTACCTGTGGTGGCAAAAGCAAGATCGCAAGGTTCTCAAAAGAAT
CAATACCCTACTCAGAGATATCCAACGCAACGGTAACGAAGGCATTGGCAAGCCAGAGGCCCTGCGCAACAACCTCTCCG
GCTACTGGTCCCGCAGAATTACTGAAGAACACCGGCTAGTCTACAAAATCGTGGGCAATTCTGTGCGCATTGCTGCGGTG
AGGTACCACTACGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References