Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 882852..883477 Replicon chromosome
Accession NZ_CP113536
Organism Salmonella enterica strain ZCX

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag OXV07_RS04320 Protein ID WP_000911336.1
Coordinates 883079..883477 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag OXV07_RS04315 Protein ID WP_000557549.1
Coordinates 882852..883079 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV07_RS04285 (877897) 877897..879414 + 1518 WP_000003339.1 lysine--tRNA ligase -
OXV07_RS04290 (879490) 879490..880035 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
OXV07_RS04295 (880300) 880300..881058 + 759 WP_000244329.1 amidase activator ActS -
OXV07_RS04305 (881343) 881343..882149 - 807 WP_010989071.1 DUF1460 domain-containing protein -
OXV07_RS04310 (882424) 882424..882675 - 252 WP_001540858.1 hypothetical protein -
OXV07_RS04315 (882852) 882852..883079 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
OXV07_RS04320 (883079) 883079..883477 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
OXV07_RS04325 (884283) 884283..884819 + 537 WP_001038506.1 STM3031 family outer membrane protein -
OXV07_RS04330 (884866) 884866..885498 + 633 WP_000835265.1 YfdX family protein -
OXV07_RS04335 (886217) 886217..886801 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 881343..892668 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T265920 WP_000911336.1 NZ_CP113536:883079-883477 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT265920 WP_000557549.1 NZ_CP113536:882852-883079 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References