294648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4132814..4133439 Replicon chromosome
Accession NZ_OU015340
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain AUSMDU00027944 isolate AUSMDU00027944

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag KKR00_RS20865 Protein ID WP_000911336.1
Coordinates 4133041..4133439 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag KKR00_RS20860 Protein ID WP_000557549.1
Coordinates 4132814..4133041 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKR00_RS20830 (4127859) 4127859..4129376 + 1518 WP_000003339.1 lysine--tRNA ligase -
KKR00_RS20835 (4129452) 4129452..4129997 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
KKR00_RS20840 (4130262) 4130262..4131020 + 759 WP_000244329.1 amidase activator ActS -
KKR00_RS20850 (4131305) 4131305..4132111 - 807 WP_010989071.1 DUF1460 domain-containing protein -
KKR00_RS20855 (4132386) 4132386..4132637 - 252 WP_001540858.1 hypothetical protein -
KKR00_RS20860 (4132814) 4132814..4133041 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
KKR00_RS20865 (4133041) 4133041..4133439 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
KKR00_RS20870 (4134245) 4134245..4134781 + 537 WP_001038506.1 STM3031 family outer membrane protein -
KKR00_RS20875 (4134828) 4134828..4135460 + 633 WP_000835265.1 YfdX family protein -
KKR00_RS20880 (4136179) 4136179..4136763 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4131305..4142630 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T294648 WP_000911336.1 NZ_OU015340:4133041-4133439 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT294648 WP_000557549.1 NZ_OU015340:4132814-4133041 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References