Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3824424..3825049 Replicon chromosome
Accession NZ_CP085803
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF50_RS18700 Protein ID WP_000911336.1
Coordinates 3824424..3824822 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF50_RS18705 Protein ID WP_000557549.1
Coordinates 3824822..3825049 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF50_RS18685 (3821101) 3821101..3821682 - 582 WP_001244651.1 fimbrial protein -
LJF50_RS18690 (3822401) 3822401..3823033 - 633 WP_000835265.1 YfdX family protein -
LJF50_RS18695 (3823080) 3823080..3823616 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF50_RS18700 (3824424) 3824424..3824822 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF50_RS18705 (3824822) 3824822..3825049 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF50_RS18710 (3825258) 3825258..3825509 + 252 WP_001576352.1 hypothetical protein -
LJF50_RS18715 (3825789) 3825789..3826595 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF50_RS18725 (3826880) 3826880..3827638 - 759 WP_000244328.1 amidase activator ActS -
LJF50_RS18730 (3827903) 3827903..3828448 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF50_RS18735 (3828524) 3828524..3830041 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3815985..3826595 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221611 WP_000911336.1 NZ_CP085803:c3824822-3824424 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221611 NZ_CP117554:1898806-1898985 [Erwinia amylovora]
ATGGATAGCAGGAATGCAATAGCAATGATAGAGGCCGATGGATGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATCCCCAAAAGGACATACCGCTACCAACGCTGAAAAGCATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221611 WP_000557549.1 NZ_CP085803:c3825049-3824822 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221611 NZ_CP117554:1899008-1899418 [Erwinia amylovora]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References