Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3782556..3783181 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag INN81_RS18490 Protein ID WP_000911336.1
Coordinates 3782556..3782954 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag INN81_RS18495 Protein ID WP_000557549.1
Coordinates 3782954..3783181 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS18475 (3779232) 3779232..3779816 - 585 WP_001244638.1 fimbrial protein -
INN81_RS18480 (3780535) 3780535..3781167 - 633 WP_000835265.1 YfdX family protein -
INN81_RS18485 (3781214) 3781214..3781750 - 537 WP_001038506.1 STM3031 family outer membrane protein -
INN81_RS18490 (3782556) 3782556..3782954 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
INN81_RS18495 (3782954) 3782954..3783181 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
INN81_RS18500 (3783358) 3783358..3783609 + 252 WP_001540858.1 hypothetical protein -
INN81_RS18505 (3783884) 3783884..3784690 + 807 WP_010989071.1 DUF1460 domain-containing protein -
INN81_RS18515 (3784975) 3784975..3785733 - 759 WP_000244329.1 amidase activator ActS -
INN81_RS18520 (3785998) 3785998..3786543 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
INN81_RS18525 (3786619) 3786619..3788136 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3774110..3784690 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233690 WP_000911336.1 NZ_CP091554:c3782954-3782556 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233690 NZ_LM995446:c443313-443095 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233690 WP_000557549.1 NZ_CP091554:c3783181-3782954 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233690 NZ_LM995446:c443713-443339 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References