186254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3133938..3134563 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag JJB81_RS15220 Protein ID WP_000911336.1
Coordinates 3133938..3134336 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag JJB81_RS15225 Protein ID WP_000557549.1
Coordinates 3134336..3134563 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS15200 (3129902) 3129902..3130486 - 585 WP_001244638.1 fimbrial protein -
JJB81_RS15205 (3131205) 3131205..3131837 - 633 WP_000835265.1 YfdX family protein -
JJB81_RS15210 (3131884) 3131884..3132420 - 537 WP_001038506.1 STM3031 family outer membrane protein -
JJB81_RS15215 (3133100) 3133100..3133558 - 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
JJB81_RS15220 (3133938) 3133938..3134336 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
JJB81_RS15225 (3134336) 3134336..3134563 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
JJB81_RS15230 (3134740) 3134740..3134991 + 252 WP_001540858.1 hypothetical protein -
JJB81_RS15235 (3135266) 3135266..3136072 + 807 WP_010989071.1 DUF1460 domain-containing protein -
JJB81_RS15245 (3136357) 3136357..3137115 - 759 WP_000244329.1 amidase activator ActS -
JJB81_RS15250 (3137380) 3137380..3137925 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
JJB81_RS15255 (3138001) 3138001..3139518 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3124780..3136072 11292
flank IS/Tn - - 3133100..3133558 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T186254 WP_000911336.1 NZ_CP067397:c3134336-3133938 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T186254 NZ_CP089307:c463130-462762 [Lacticaseibacillus paracasei]
ATGTATAAAATTGACTTCTATGAGGATCGCGATGGCTACTCTGAGATCGAAGACTTTCTTGATCAGTTACGCCATAGTCA
TCAAAAAAATAATGTGAGCCTTTTAAACAAAATCACAAAGGAACTCTACATGCTGCAAAATCTTGGTCCGCGCTTACGTG
AACCTCACGCGAAGTTTCTGAAGGGATATGCTTATCCGATCATGGAATTGCGTCCCATGCAAGAAAGAATCTTTTATGCT
GCATGGCAAAAGGATCATTTCGTTTTGCTTCATCACTACACCAAGAAAACAAACAAAACTGATCACAGAGAAATTTTACG
GGCACAGTCTAACCTCGAAGATTGGCTCTCTAGAAAGGAAGAAAATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT186254 WP_000557549.1 NZ_CP067397:c3134563-3134336 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT186254 NZ_CP089307:c462762-462502 [Lacticaseibacillus paracasei]
ATGACGACATGGGAAGACTTCAGTCAGAAACTGAAGAAGGACAATCCAGAAAAGTTGGCAATCATCAAAACCTTGGCCGA
TTTAGAAAGTGAACGAATCAAGCAAGGAATCTCTCAAAAGGACTTTGCAGAAAAAATTGGTATGAAACAGCCGCAACTAG
CAAAGATTGAGCGCTTAGACTCTCTTCCGACTCTGGCAACACTCAATCGATACGCGAGAGGGCTTGGAAAAGAAATTCGT
TTATCAATTGTTACTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References