Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3195162..3195787 Replicon chromosome
Accession NZ_CP074092
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SO_8752_Stm

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag KFK83_RS15545 Protein ID WP_000911336.1
Coordinates 3195162..3195560 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag KFK83_RS15550 Protein ID WP_000557549.1
Coordinates 3195560..3195787 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFK83_RS15525 (3191126) 3191126..3191710 - 585 WP_001244638.1 fimbrial protein -
KFK83_RS15530 (3192429) 3192429..3193061 - 633 WP_000835265.1 YfdX family protein -
KFK83_RS15535 (3193108) 3193108..3193644 - 537 WP_001038506.1 STM3031 family outer membrane protein -
KFK83_RS15540 (3194324) 3194324..3194782 - 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
KFK83_RS15545 (3195162) 3195162..3195560 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
KFK83_RS15550 (3195560) 3195560..3195787 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
KFK83_RS15555 (3195964) 3195964..3196215 + 252 WP_001540858.1 hypothetical protein -
KFK83_RS15560 (3196490) 3196490..3197296 + 807 WP_010989071.1 DUF1460 domain-containing protein -
KFK83_RS15570 (3197581) 3197581..3198339 - 759 WP_000244329.1 amidase activator ActS -
KFK83_RS15575 (3198604) 3198604..3199149 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
KFK83_RS15580 (3199225) 3199225..3200742 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3186004..3197296 11292
flank IS/Tn - - 3194324..3194782 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T201377 WP_000911336.1 NZ_CP074092:c3195560-3195162 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T201377 NZ_CP098347:c5421255-5420872 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT201377 WP_000557549.1 NZ_CP074092:c3195787-3195560 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT201377 NZ_CP098347:c5421497-5421255 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References