212649

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 880996..881621 Replicon chromosome
Accession NZ_CP081187
Organism Salmonella enterica strain sg1722-1

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag K4F82_RS04295 Protein ID WP_000911336.1
Coordinates 881223..881621 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag K4F82_RS04290 Protein ID WP_000557549.1
Coordinates 880996..881223 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F82_RS04260 (876041) 876041..877558 + 1518 WP_000003339.1 lysine--tRNA ligase -
K4F82_RS04265 (877634) 877634..878179 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
K4F82_RS04270 (878444) 878444..879202 + 759 WP_000244329.1 amidase activator ActS -
K4F82_RS04280 (879487) 879487..880293 - 807 WP_010989071.1 DUF1460 domain-containing protein -
K4F82_RS04285 (880568) 880568..880819 - 252 WP_001540858.1 hypothetical protein -
K4F82_RS04290 (880996) 880996..881223 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
K4F82_RS04295 (881223) 881223..881621 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
K4F82_RS04300 (882427) 882427..882963 + 537 WP_001038506.1 STM3031 family outer membrane protein -
K4F82_RS04305 (883010) 883010..883642 + 633 WP_000835265.1 YfdX family protein -
K4F82_RS04310 (884361) 884361..884945 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879487..890812 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T212649 WP_000911336.1 NZ_CP081187:881223-881621 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T212649 NZ_CP107308:c4784240-4783707 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT212649 WP_000557549.1 NZ_CP081187:880996-881223 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT212649 NZ_CP107308:c4784517-4784251 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References