Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881318..881943 Replicon chromosome
Accession NZ_CP047525
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN14_RS04295 Protein ID WP_000911336.1
Coordinates 881545..881943 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN14_RS04290 Protein ID WP_000557549.1
Coordinates 881318..881545 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN14_RS04260 (876363) 876363..877880 + 1518 WP_000003339.1 lysine--tRNA ligase -
DXN14_RS04265 (877956) 877956..878501 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN14_RS04270 (878766) 878766..879524 + 759 WP_000244329.1 amidase activator ActS -
DXN14_RS04280 (879809) 879809..880615 - 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN14_RS04285 (880890) 880890..881141 - 252 WP_001540858.1 hypothetical protein -
DXN14_RS04290 (881318) 881318..881545 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN14_RS04295 (881545) 881545..881943 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN14_RS04300 (882749) 882749..883285 + 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN14_RS04305 (883332) 883332..883964 + 633 WP_000835265.1 YfdX family protein -
DXN14_RS04310 (884683) 884683..885267 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879809..891134 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146361 WP_000911336.1 NZ_CP047525:881545-881943 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146361 NZ_CP062743:71579-71737 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146361 WP_000557549.1 NZ_CP047525:881318-881545 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146361 NZ_CP062743:71316-71514 [Escherichia coli O157:H7]
TCACACGGATTGCCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References