170668

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3425006..3425631 Replicon chromosome
Accession NZ_CP060674
Organism Salmonella enterica strain 190729_4

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag H9Q84_RS16730 Protein ID WP_000911336.1
Coordinates 3425006..3425404 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag H9Q84_RS16735 Protein ID WP_000557549.1
Coordinates 3425404..3425631 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q84_RS16715 (3421683) 3421683..3422264 - 582 WP_001244651.1 fimbrial protein -
H9Q84_RS16720 (3422983) 3422983..3423615 - 633 WP_000835265.1 YfdX family protein -
H9Q84_RS16725 (3423662) 3423662..3424198 - 537 WP_001038502.1 STM3031 family outer membrane protein -
H9Q84_RS16730 (3425006) 3425006..3425404 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
H9Q84_RS16735 (3425404) 3425404..3425631 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9Q84_RS16740 (3425840) 3425840..3426091 + 252 WP_001576352.1 hypothetical protein -
H9Q84_RS16745 (3426371) 3426371..3427177 + 807 WP_001574939.1 DUF1460 domain-containing protein -
H9Q84_RS16755 (3427462) 3427462..3428220 - 759 WP_000244328.1 amidase activator ActS -
H9Q84_RS16760 (3428485) 3428485..3429030 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
H9Q84_RS16765 (3429106) 3429106..3430623 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3416567..3427177 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T170668 WP_000911336.1 NZ_CP060674:c3425404-3425006 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T170668 NZ_CP077670:c4076206-4075922 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT170668 WP_000557549.1 NZ_CP060674:c3425631-3425404 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT170668 NZ_CP077670:c4076438-4076196 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTACGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References