239672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 849215..849840 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag MQF88_RS04095 Protein ID WP_000911336.1
Coordinates 849442..849840 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag MQF88_RS04090 Protein ID WP_000557549.1
Coordinates 849215..849442 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS04060 (844260) 844260..845777 + 1518 WP_000003339.1 lysine--tRNA ligase -
MQF88_RS04065 (845853) 845853..846398 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
MQF88_RS04070 (846663) 846663..847421 + 759 WP_000244329.1 amidase activator ActS -
MQF88_RS04080 (847706) 847706..848512 - 807 WP_010989071.1 DUF1460 domain-containing protein -
MQF88_RS04085 (848787) 848787..849038 - 252 WP_001540858.1 hypothetical protein -
MQF88_RS04090 (849215) 849215..849442 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
MQF88_RS04095 (849442) 849442..849840 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
MQF88_RS04100 (850646) 850646..851182 + 537 WP_001038506.1 STM3031 family outer membrane protein -
MQF88_RS04105 (851229) 851229..851861 + 633 WP_000835265.1 YfdX family protein -
MQF88_RS04110 (852580) 852580..853164 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 847706..859031 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T239672 WP_000911336.1 NZ_CP094332:849442-849840 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T239672 NZ_LS483301:c2262634-2262425 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT239672 WP_000557549.1 NZ_CP094332:849215-849442 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT239672 NZ_LS483301:c2262939-2262646 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References