270610

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 849197..849822 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PQP94_RS04110 Protein ID WP_274895861.1
Coordinates 849424..849822 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PQP94_RS04105 Protein ID WP_000557549.1
Coordinates 849197..849424 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS04075 (844242) 844242..845759 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQP94_RS04080 (845835) 845835..846380 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PQP94_RS04085 (846645) 846645..847403 + 759 WP_000244329.1 amidase activator ActS -
PQP94_RS04095 (847688) 847688..848494 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PQP94_RS04100 (848769) 848769..849020 - 252 WP_001540858.1 hypothetical protein -
PQP94_RS04105 (849197) 849197..849424 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQP94_RS04110 (849424) 849424..849822 + 399 WP_274895861.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQP94_RS04115 (850628) 850628..851164 + 537 WP_001038506.1 STM3031 family outer membrane protein -
PQP94_RS04120 (851211) 851211..851843 + 633 WP_000835265.1 YfdX family protein -
PQP94_RS04125 (852562) 852562..853146 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 847688..859013 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14880.26 Da        Isoelectric Point: 7.7784

>T270610 WP_274895861.1 NZ_CP117338:849424-849822 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVAGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT270610 WP_000557549.1 NZ_CP117338:849197-849424 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References