252057

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 929955..930580 Replicon chromosome
Accession NZ_CP101382
Organism Salmonella enterica strain SC2017030

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NMU36_RS04530 Protein ID WP_000911336.1
Coordinates 930182..930580 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NMU36_RS04525 Protein ID WP_000557549.1
Coordinates 929955..930182 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU36_RS04495 (925000) 925000..926517 + 1518 WP_000003339.1 lysine--tRNA ligase -
NMU36_RS04500 (926593) 926593..927138 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NMU36_RS04505 (927403) 927403..928161 + 759 WP_000244329.1 amidase activator ActS -
NMU36_RS04515 (928446) 928446..929252 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NMU36_RS04520 (929527) 929527..929778 - 252 WP_001540858.1 hypothetical protein -
NMU36_RS04525 (929955) 929955..930182 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMU36_RS04530 (930182) 930182..930580 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NMU36_RS04535 (931386) 931386..931922 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NMU36_RS04540 (931969) 931969..932601 + 633 WP_000835265.1 YfdX family protein -
NMU36_RS04545 (933320) 933320..933904 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 928446..939771 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T252057 WP_000911336.1 NZ_CP101382:930182-930580 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT252057 WP_000557549.1 NZ_CP101382:929955-930182 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References