264086

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1233728..1234353 Replicon chromosome
Accession NZ_CP110657
Organism Salmonella enterica subsp. enterica strain S2122

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag OOK64_RS06240 Protein ID WP_000911336.1
Coordinates 1233728..1234126 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag OOK64_RS06245 Protein ID WP_000557549.1
Coordinates 1234126..1234353 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOK64_RS06225 (1230404) 1230404..1230988 - 585 WP_001244638.1 fimbrial protein -
OOK64_RS06230 (1231707) 1231707..1232339 - 633 WP_000835265.1 YfdX family protein -
OOK64_RS06235 (1232386) 1232386..1232922 - 537 WP_001038506.1 STM3031 family outer membrane protein -
OOK64_RS06240 (1233728) 1233728..1234126 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
OOK64_RS06245 (1234126) 1234126..1234353 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
OOK64_RS06250 (1234530) 1234530..1234781 + 252 WP_001540858.1 hypothetical protein -
OOK64_RS06255 (1235056) 1235056..1235862 + 807 WP_010989071.1 DUF1460 domain-containing protein -
OOK64_RS06265 (1236147) 1236147..1236905 - 759 WP_000244329.1 amidase activator ActS -
OOK64_RS06270 (1237170) 1237170..1237715 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
OOK64_RS06275 (1237791) 1237791..1239308 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1225282..1235862 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T264086 WP_000911336.1 NZ_CP110657:c1234126-1233728 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT264086 WP_000557549.1 NZ_CP110657:c1234353-1234126 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References