Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 849208..849833 Replicon chromosome
Accession NZ_CP091542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S58L2

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag L5Z53_RS04110 Protein ID WP_000911336.1
Coordinates 849435..849833 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag L5Z53_RS04105 Protein ID WP_000557549.1
Coordinates 849208..849435 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5Z53_RS04075 (844253) 844253..845770 + 1518 WP_000003339.1 lysine--tRNA ligase -
L5Z53_RS04080 (845846) 845846..846391 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
L5Z53_RS04085 (846656) 846656..847414 + 759 WP_000244329.1 amidase activator ActS -
L5Z53_RS04095 (847699) 847699..848505 - 807 WP_010989071.1 DUF1460 domain-containing protein -
L5Z53_RS04100 (848780) 848780..849031 - 252 WP_001540858.1 hypothetical protein -
L5Z53_RS04105 (849208) 849208..849435 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
L5Z53_RS04110 (849435) 849435..849833 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
L5Z53_RS04115 (850639) 850639..851175 + 537 WP_001038506.1 STM3031 family outer membrane protein -
L5Z53_RS04120 (851222) 851222..851854 + 633 WP_000835265.1 YfdX family protein -
L5Z53_RS04125 (852573) 852573..853157 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 847699..859024 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233600 WP_000911336.1 NZ_CP091542:849435-849833 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233600 NZ_HG994851:2554420-2554698 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233600 WP_000557549.1 NZ_CP091542:849208-849435 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233600 NZ_HG994851:2554698-2554982 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References