146631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4107917..4108542 Replicon chromosome
Accession NZ_CP047548
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10169

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN26_RS20135 Protein ID WP_000911336.1
Coordinates 4107917..4108315 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN26_RS20140 Protein ID WP_000557549.1
Coordinates 4108315..4108542 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN26_RS20120 (4104593) 4104593..4105177 - 585 WP_001244638.1 fimbrial protein -
DXN26_RS20125 (4105896) 4105896..4106528 - 633 WP_000835265.1 YfdX family protein -
DXN26_RS20130 (4106575) 4106575..4107111 - 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN26_RS20135 (4107917) 4107917..4108315 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN26_RS20140 (4108315) 4108315..4108542 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN26_RS20145 (4108719) 4108719..4108970 + 252 WP_001540858.1 hypothetical protein -
DXN26_RS20150 (4109245) 4109245..4110051 + 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN26_RS20160 (4110336) 4110336..4111094 - 759 WP_000244329.1 amidase activator ActS -
DXN26_RS20165 (4111359) 4111359..4111904 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN26_RS20170 (4111980) 4111980..4113497 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4099471..4110051 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146631 WP_000911336.1 NZ_CP047548:c4108315-4107917 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146631 NZ_CP062769:365365-365640 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146631 WP_000557549.1 NZ_CP047548:c4108542-4108315 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146631 NZ_CP062769:365637-365996 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References