251218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 904183..904808 Replicon chromosome
Accession NZ_CP100724
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R17.1476

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NL714_RS04290 Protein ID WP_000911336.1
Coordinates 904183..904581 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NL714_RS04295 Protein ID WP_000557549.1
Coordinates 904581..904808 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL714_RS04275 (900860) 900860..901441 - 582 WP_001244651.1 fimbrial protein -
NL714_RS04280 (902160) 902160..902792 - 633 WP_000835265.1 YfdX family protein -
NL714_RS04285 (902839) 902839..903375 - 537 WP_001038502.1 STM3031 family outer membrane protein -
NL714_RS04290 (904183) 904183..904581 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NL714_RS04295 (904581) 904581..904808 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL714_RS04300 (905017) 905017..905268 + 252 WP_001576352.1 hypothetical protein -
NL714_RS04305 (905548) 905548..906354 + 807 WP_001574939.1 DUF1460 domain-containing protein -
NL714_RS04315 (906639) 906639..907397 - 759 WP_000244328.1 amidase activator ActS -
NL714_RS04320 (907662) 907662..908207 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NL714_RS04325 (908283) 908283..909800 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 895744..906354 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T251218 WP_000911336.1 NZ_CP100724:c904581-904183 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT251218 WP_000557549.1 NZ_CP100724:c904808-904581 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References