Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 880877..881502 Replicon chromosome
Accession NZ_CP117033
Organism Salmonella enterica strain PIW95_S14_0299

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag PQP07_RS04300 Protein ID WP_000911336.1
Coordinates 881104..881502 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PQP07_RS04295 Protein ID WP_000557549.1
Coordinates 880877..881104 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP07_RS04265 (875922) 875922..877439 + 1518 WP_000003339.1 lysine--tRNA ligase -
PQP07_RS04270 (877515) 877515..878060 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PQP07_RS04275 (878325) 878325..879083 + 759 WP_000244329.1 amidase activator ActS -
PQP07_RS04285 (879368) 879368..880174 - 807 WP_010989071.1 DUF1460 domain-containing protein -
PQP07_RS04290 (880449) 880449..880700 - 252 WP_001540858.1 hypothetical protein -
PQP07_RS04295 (880877) 880877..881104 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQP07_RS04300 (881104) 881104..881502 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQP07_RS04305 (882308) 882308..882844 + 537 WP_001038506.1 STM3031 family outer membrane protein -
PQP07_RS04310 (882891) 882891..883523 + 633 WP_000835265.1 YfdX family protein -
PQP07_RS04315 (884242) 884242..884826 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879368..890693 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T269883 WP_000911336.1 NZ_CP117033:881104-881502 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT269883 WP_000557549.1 NZ_CP117033:880877-881104 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References