265954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 878970..879595 Replicon chromosome
Accession NZ_CP113538
Organism Salmonella enterica strain XSK

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag OXV06_RS04220 Protein ID WP_000911336.1
Coordinates 879197..879595 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag OXV06_RS04215 Protein ID WP_000557549.1
Coordinates 878970..879197 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV06_RS04185 (874015) 874015..875532 + 1518 WP_000003339.1 lysine--tRNA ligase -
OXV06_RS04190 (875608) 875608..876153 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
OXV06_RS04195 (876418) 876418..877176 + 759 WP_000244329.1 amidase activator ActS -
OXV06_RS04205 (877461) 877461..878267 - 807 WP_010989071.1 DUF1460 domain-containing protein -
OXV06_RS04210 (878542) 878542..878793 - 252 WP_001540858.1 hypothetical protein -
OXV06_RS04215 (878970) 878970..879197 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
OXV06_RS04220 (879197) 879197..879595 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
OXV06_RS04225 (880401) 880401..880937 + 537 WP_001038506.1 STM3031 family outer membrane protein -
OXV06_RS04230 (880984) 880984..881616 + 633 WP_000835265.1 YfdX family protein -
OXV06_RS04235 (882335) 882335..882919 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 877461..888786 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T265954 WP_000911336.1 NZ_CP113538:879197-879595 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT265954 WP_000557549.1 NZ_CP113538:878970-879197 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References