Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 931253..931878 Replicon chromosome
Accession NZ_CP075372
Organism Salmonella enterica strain no75

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag KH432_RS04535 Protein ID WP_000911336.1
Coordinates 931480..931878 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag KH432_RS04530 Protein ID WP_000557549.1
Coordinates 931253..931480 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH432_RS04500 (926298) 926298..927815 + 1518 WP_000003339.1 lysine--tRNA ligase -
KH432_RS04505 (927891) 927891..928436 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
KH432_RS04510 (928701) 928701..929459 + 759 WP_000244329.1 amidase activator ActS -
KH432_RS04520 (929744) 929744..930550 - 807 WP_010989071.1 DUF1460 domain-containing protein -
KH432_RS04525 (930825) 930825..931076 - 252 WP_001540858.1 hypothetical protein -
KH432_RS04530 (931253) 931253..931480 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
KH432_RS04535 (931480) 931480..931878 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
KH432_RS04540 (932684) 932684..933220 + 537 WP_001038506.1 STM3031 family outer membrane protein -
KH432_RS04545 (933267) 933267..933899 + 633 WP_000835265.1 YfdX family protein -
KH432_RS04550 (934618) 934618..935202 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 929744..941069 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T203513 WP_000911336.1 NZ_CP075372:931480-931878 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T203513 NZ_CP100107:181297-181713 [Klebsiella pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT203513 WP_000557549.1 NZ_CP075372:931253-931480 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT203513 NZ_CP100107:181070-181300 [Klebsiella pneumoniae]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References