187603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1321482..1322107 Replicon chromosome
Accession NZ_CP068696
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag JKV46_RS06505 Protein ID WP_000911336.1
Coordinates 1321709..1322107 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag JKV46_RS06500 Protein ID WP_000557549.1
Coordinates 1321482..1321709 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV46_RS06470 (1316527) 1316527..1318044 + 1518 WP_000003339.1 lysine--tRNA ligase -
JKV46_RS06475 (1318120) 1318120..1318665 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
JKV46_RS06480 (1318930) 1318930..1319688 + 759 WP_000244329.1 amidase activator ActS -
JKV46_RS06490 (1319973) 1319973..1320779 - 807 WP_010989071.1 DUF1460 domain-containing protein -
JKV46_RS06495 (1321054) 1321054..1321305 - 252 WP_001540858.1 hypothetical protein -
JKV46_RS06500 (1321482) 1321482..1321709 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
JKV46_RS06505 (1321709) 1321709..1322107 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
JKV46_RS06510 (1322913) 1322913..1323449 + 537 WP_001038506.1 STM3031 family outer membrane protein -
JKV46_RS06515 (1323496) 1323496..1324128 + 633 WP_000835265.1 YfdX family protein -
JKV46_RS06520 (1324847) 1324847..1325431 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1319973..1331298 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T187603 WP_000911336.1 NZ_CP068696:1321709-1322107 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T187603 NZ_CP089927:1856141-1856581 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT187603 WP_000557549.1 NZ_CP068696:1321482-1321709 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT187603 NZ_CP089927:1855867-1856154 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References