251037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 928852..929477 Replicon chromosome
Accession NZ_CP100691
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.3867

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NL690_RS04525 Protein ID WP_000911336.1
Coordinates 929079..929477 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NL690_RS04520 Protein ID WP_000557549.1
Coordinates 928852..929079 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL690_RS04490 (923897) 923897..925414 + 1518 WP_000003339.1 lysine--tRNA ligase -
NL690_RS04495 (925490) 925490..926035 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NL690_RS04500 (926300) 926300..927058 + 759 WP_000244329.1 amidase activator ActS -
NL690_RS04510 (927343) 927343..928149 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NL690_RS04515 (928424) 928424..928675 - 252 WP_001540858.1 hypothetical protein -
NL690_RS04520 (928852) 928852..929079 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL690_RS04525 (929079) 929079..929477 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NL690_RS04530 (930283) 930283..930819 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NL690_RS04535 (930866) 930866..931498 + 633 WP_000835265.1 YfdX family protein -
NL690_RS04540 (932217) 932217..932801 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 927343..938668 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T251037 WP_000911336.1 NZ_CP100691:929079-929477 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT251037 WP_000557549.1 NZ_CP100691:928852-929079 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References