233859

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881193..881818 Replicon chromosome
Accession NZ_CP091571
Organism Salmonella enterica strain

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag INN74_RS04290 Protein ID WP_000911336.1
Coordinates 881420..881818 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag INN74_RS04285 Protein ID WP_000557549.1
Coordinates 881193..881420 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN74_RS04255 (876238) 876238..877755 + 1518 WP_000003339.1 lysine--tRNA ligase -
INN74_RS04260 (877831) 877831..878376 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
INN74_RS04265 (878641) 878641..879399 + 759 WP_000244329.1 amidase activator ActS -
INN74_RS04275 (879684) 879684..880490 - 807 WP_010989071.1 DUF1460 domain-containing protein -
INN74_RS04280 (880765) 880765..881016 - 252 WP_001540858.1 hypothetical protein -
INN74_RS04285 (881193) 881193..881420 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
INN74_RS04290 (881420) 881420..881818 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
INN74_RS04295 (882624) 882624..883160 + 537 WP_001038506.1 STM3031 family outer membrane protein -
INN74_RS04300 (883207) 883207..883839 + 633 WP_000835265.1 YfdX family protein -
INN74_RS04305 (884558) 884558..885142 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879684..890628 10944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233859 WP_000911336.1 NZ_CP091571:881420-881818 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233859 NZ_LN832404:c246407-246129 [Escherichia coli K-12]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233859 WP_000557549.1 NZ_CP091571:881193-881420 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233859 NZ_LN832404:c246670-246410 [Escherichia coli K-12]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References