252077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 961931..962556 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NMU37_RS04725 Protein ID WP_000911336.1
Coordinates 962158..962556 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NMU37_RS04720 Protein ID WP_000557549.1
Coordinates 961931..962158 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS04690 (956976) 956976..958493 + 1518 WP_000003339.1 lysine--tRNA ligase -
NMU37_RS04695 (958569) 958569..959114 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NMU37_RS04700 (959379) 959379..960137 + 759 WP_000244329.1 amidase activator ActS -
NMU37_RS04710 (960422) 960422..961228 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NMU37_RS04715 (961503) 961503..961754 - 252 WP_001540858.1 hypothetical protein -
NMU37_RS04720 (961931) 961931..962158 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NMU37_RS04725 (962158) 962158..962556 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NMU37_RS04730 (963362) 963362..963898 + 537 WP_001038506.1 STM3031 family outer membrane protein -
NMU37_RS04735 (963945) 963945..964577 + 633 WP_000835265.1 YfdX family protein -
NMU37_RS04740 (965296) 965296..965880 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 960422..971747 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T252077 WP_000911336.1 NZ_CP101386:962158-962556 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT252077 WP_000557549.1 NZ_CP101386:961931-962158 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References