270051

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3861864..3862489 Replicon chromosome
Accession NZ_CP117184
Organism Salmonella enterica subsp. enterica strain 123

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag PQ453_RS19110 Protein ID WP_000911336.1
Coordinates 3861864..3862262 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PQ453_RS19115 Protein ID WP_000557549.1
Coordinates 3862262..3862489 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ453_RS19095 (3858540) 3858540..3859124 - 585 WP_001244638.1 fimbrial protein -
PQ453_RS19100 (3859843) 3859843..3860475 - 633 WP_000835265.1 YfdX family protein -
PQ453_RS19105 (3860522) 3860522..3861058 - 537 WP_001038506.1 STM3031 family outer membrane protein -
PQ453_RS19110 (3861864) 3861864..3862262 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
PQ453_RS19115 (3862262) 3862262..3862489 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQ453_RS19120 (3862666) 3862666..3862917 + 252 WP_001540858.1 hypothetical protein -
PQ453_RS19125 (3863192) 3863192..3863998 + 807 WP_010989071.1 DUF1460 domain-containing protein -
PQ453_RS19135 (3864283) 3864283..3865041 - 759 WP_000244329.1 amidase activator ActS -
PQ453_RS19140 (3865306) 3865306..3865851 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PQ453_RS19145 (3865927) 3865927..3867444 - 1518 WP_273692499.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3853418..3863998 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T270051 WP_000911336.1 NZ_CP117184:c3862262-3861864 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT270051 WP_000557549.1 NZ_CP117184:c3862489-3862262 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References