Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1917500..1918125 Replicon chromosome
Accession NZ_CP085823
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Venusaur

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF47_RS09525 Protein ID WP_000911336.1
Coordinates 1917500..1917898 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF47_RS09530 Protein ID WP_000557549.1
Coordinates 1917898..1918125 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF47_RS09510 (1914177) 1914177..1914758 - 582 WP_001244651.1 fimbrial protein -
LJF47_RS09515 (1915477) 1915477..1916109 - 633 WP_000835265.1 YfdX family protein -
LJF47_RS09520 (1916156) 1916156..1916692 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF47_RS09525 (1917500) 1917500..1917898 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF47_RS09530 (1917898) 1917898..1918125 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF47_RS09535 (1918334) 1918334..1918585 + 252 WP_001576352.1 hypothetical protein -
LJF47_RS09540 (1918865) 1918865..1919671 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF47_RS09550 (1919956) 1919956..1920714 - 759 WP_000244328.1 amidase activator ActS -
LJF47_RS09555 (1920979) 1920979..1921524 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF47_RS09560 (1921600) 1921600..1923117 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1909061..1919671 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T222066 WP_000911336.1 NZ_CP085823:c1917898-1917500 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T222066 NZ_CP117672:c594805-594341 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT222066 WP_000557549.1 NZ_CP085823:c1918125-1917898 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT222066 NZ_CP117672:c595140-594805 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References