Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 961818..962443 Replicon chromosome
Accession NZ_CP090539
Organism Salmonella enterica strain 2016062-SE

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag L0F59_RS04720 Protein ID WP_000911336.1
Coordinates 962045..962443 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag L0F59_RS04715 Protein ID WP_000557549.1
Coordinates 961818..962045 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F59_RS04685 (956863) 956863..958380 + 1518 WP_000003339.1 lysine--tRNA ligase -
L0F59_RS04690 (958456) 958456..959001 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
L0F59_RS04695 (959266) 959266..960024 + 759 WP_000244329.1 amidase activator ActS -
L0F59_RS04705 (960309) 960309..961115 - 807 WP_010989071.1 DUF1460 domain-containing protein -
L0F59_RS04710 (961390) 961390..961641 - 252 WP_001540858.1 hypothetical protein -
L0F59_RS04715 (961818) 961818..962045 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
L0F59_RS04720 (962045) 962045..962443 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
L0F59_RS04725 (963249) 963249..963785 + 537 WP_001038506.1 STM3031 family outer membrane protein -
L0F59_RS04730 (963832) 963832..964464 + 633 WP_000835265.1 YfdX family protein -
L0F59_RS04735 (965183) 965183..965767 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 960309..971634 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T231097 WP_000911336.1 NZ_CP090539:962045-962443 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T231097 NZ_CP125966:583239-583511 [Helicobacter pylori]
ATGCTGATGATTGAAATCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAACCAAAGAGCAACCCCTAGATCCCAAATATAAAGACCACCCGCTCAAAGGTGCTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAATACCCTCTTTTTA
GTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT231097 WP_000557549.1 NZ_CP090539:961818-962045 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT231097 NZ_CP125966:582941-583252 [Helicobacter pylori]
ATGCCTAATTCTCCCGCCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAATATAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References