276255

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1194879..1195504 Replicon chromosome
Accession NZ_CP121298
Organism Salmonella enterica subsp. enterica strain KKP 3080

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag P1839_RS05795 Protein ID WP_000911336.1
Coordinates 1195106..1195504 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag P1839_RS05790 Protein ID WP_000557549.1
Coordinates 1194879..1195106 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1839_RS05760 (1189924) 1189924..1191441 + 1518 WP_000003339.1 lysine--tRNA ligase -
P1839_RS05765 (1191517) 1191517..1192062 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
P1839_RS05770 (1192327) 1192327..1193085 + 759 WP_000244329.1 amidase activator ActS -
P1839_RS05780 (1193370) 1193370..1194176 - 807 WP_185609406.1 DUF1460 domain-containing protein -
P1839_RS05785 (1194451) 1194451..1194702 - 252 WP_001540858.1 hypothetical protein -
P1839_RS05790 (1194879) 1194879..1195106 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1839_RS05795 (1195106) 1195106..1195504 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
P1839_RS05800 (1196310) 1196310..1196846 + 537 WP_278219242.1 STM3031 family outer membrane protein -
P1839_RS05805 (1196893) 1196893..1197525 + 633 WP_000835265.1 YfdX family protein -
P1839_RS05810 (1198244) 1198244..1198828 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1194451..1204695 10244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T276255 WP_000911336.1 NZ_CP121298:1195106-1195504 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT276255 WP_000557549.1 NZ_CP121298:1194879-1195106 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References