170608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3094537..3095162 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag H9Q86_RS15145 Protein ID WP_000911336.1
Coordinates 3094537..3094935 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag H9Q86_RS15150 Protein ID WP_000557549.1
Coordinates 3094935..3095162 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS15130 (3091214) 3091214..3091795 - 582 WP_001244651.1 fimbrial protein -
H9Q86_RS15135 (3092514) 3092514..3093146 - 633 WP_000835265.1 YfdX family protein -
H9Q86_RS15140 (3093193) 3093193..3093729 - 537 WP_001038502.1 STM3031 family outer membrane protein -
H9Q86_RS15145 (3094537) 3094537..3094935 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
H9Q86_RS15150 (3094935) 3094935..3095162 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
H9Q86_RS15155 (3095371) 3095371..3095622 + 252 WP_001576352.1 hypothetical protein -
H9Q86_RS15160 (3095902) 3095902..3096708 + 807 WP_001574939.1 DUF1460 domain-containing protein -
H9Q86_RS15170 (3096993) 3096993..3097751 - 759 WP_000244328.1 amidase activator ActS -
H9Q86_RS15175 (3098016) 3098016..3098561 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
H9Q86_RS15180 (3098637) 3098637..3100154 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3086098..3096708 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T170608 WP_000911336.1 NZ_CP060670:c3094935-3094537 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T170608 NZ_CP077659:3152384-3152683 [Enterobacter cloacae complex sp. ECL72]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT170608 WP_000557549.1 NZ_CP060670:c3095162-3094935 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT170608 NZ_CP077659:3152694-3153059 [Enterobacter cloacae complex sp. ECL72]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References