233740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3721864..3722489 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag INN79_RS18470 Protein ID WP_000911336.1
Coordinates 3722091..3722489 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag INN79_RS18465 Protein ID WP_000557549.1
Coordinates 3721864..3722091 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS18435 (3716909) 3716909..3718426 + 1518 WP_000003339.1 lysine--tRNA ligase -
INN79_RS18440 (3718502) 3718502..3719047 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
INN79_RS18445 (3719312) 3719312..3720070 + 759 WP_000244329.1 amidase activator ActS -
INN79_RS18455 (3720355) 3720355..3721161 - 807 WP_010989071.1 DUF1460 domain-containing protein -
INN79_RS18460 (3721436) 3721436..3721687 - 252 WP_001540858.1 hypothetical protein -
INN79_RS18465 (3721864) 3721864..3722091 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
INN79_RS18470 (3722091) 3722091..3722489 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
INN79_RS18475 (3723295) 3723295..3723831 + 537 WP_001038506.1 STM3031 family outer membrane protein -
INN79_RS18480 (3723878) 3723878..3724510 + 633 WP_000835265.1 YfdX family protein -
INN79_RS18485 (3725229) 3725229..3725813 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3720355..3731680 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233740 WP_000911336.1 NZ_CP091558:3722091-3722489 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233740 NZ_LN626917:c2535268-2535002 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233740 WP_000557549.1 NZ_CP091558:3721864-3722091 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233740 NZ_LN626917:c2535519-2535268 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References