233627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 964265..964890 Replicon chromosome
Accession NZ_CP091544
Organism Salmonella enterica strain 1618

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag L4414_RS04745 Protein ID WP_000911336.1
Coordinates 964492..964890 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag L4414_RS04740 Protein ID WP_000557549.1
Coordinates 964265..964492 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4414_RS04710 (959310) 959310..960827 + 1518 WP_000003339.1 lysine--tRNA ligase -
L4414_RS04715 (960903) 960903..961448 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
L4414_RS04720 (961713) 961713..962471 + 759 WP_000244329.1 amidase activator ActS -
L4414_RS04730 (962756) 962756..963562 - 807 WP_010989071.1 DUF1460 domain-containing protein -
L4414_RS04735 (963837) 963837..964088 - 252 WP_001540858.1 hypothetical protein -
L4414_RS04740 (964265) 964265..964492 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
L4414_RS04745 (964492) 964492..964890 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
L4414_RS04750 (965696) 965696..966232 + 537 WP_001038506.1 STM3031 family outer membrane protein -
L4414_RS04755 (966279) 966279..966911 + 633 WP_000835265.1 YfdX family protein -
L4414_RS04760 (967630) 967630..968214 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 962756..974081 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233627 WP_000911336.1 NZ_CP091544:964492-964890 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233627 NZ_HG999364:65878-66177 [Xanthomonas euroxanthea]
ATGGCTGAAATAGTCTGGTCGGAGCCGGCGGTGGCCGACCTGGACGCGATTGCCGACTACATTGCACTTGAGGACGCAGC
CGCCGCAGCGGCACTGGTGAGACGGGTGGTTGCGCATGTCGAGCAATTGGCCGAGCACCCGGAGAGCGGGAGCCGCCCGC
AGGAGCTCAAGCGCTCCCGCTACCGTCAAATCGTCGAACCACCGTGCCGCGTGTTCTACCGTGTGGATGGGCAGCGCGTC
GTCGTGGTTCACGTGATGCGCTCGGAGCGGTTACTCCGGAGAAATCGTCTTTCGCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233627 WP_000557549.1 NZ_CP091544:964265-964492 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233627 NZ_HG999364:65633-65890 [Xanthomonas euroxanthea]
ATGCGCACAGAACTTGTCACCACGCTCAAGCGTCAGGCCACCGAACTCCTCGCTGATGTCGAGCGCGACAAGGAGCCGAT
CCTGATTACCCAGCATGGTCTGCCCAGCGCATATCTGGTCGATGTCACCAGCTATGAGCGCCTGCAGCAGCGGATGGCGA
TCCTCGAAGGTATCGCCCGTGGTGAAATGGCGGTAGCGGAAGGCCGCAGCCTGAGCCACGAGCAGGCCAAACAACGCCTG
GCGCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References