233790

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3863181..3863806 Replicon chromosome
Accession NZ_CP091563
Organism Salmonella enterica strain 143

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag INN77_RS19110 Protein ID WP_000911336.1
Coordinates 3863181..3863579 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag INN77_RS19115 Protein ID WP_000557549.1
Coordinates 3863579..3863806 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN77_RS19095 (3859857) 3859857..3860441 - 585 WP_001244638.1 fimbrial protein -
INN77_RS19100 (3861160) 3861160..3861792 - 633 WP_000835265.1 YfdX family protein -
INN77_RS19105 (3861839) 3861839..3862375 - 537 WP_001038506.1 STM3031 family outer membrane protein -
INN77_RS19110 (3863181) 3863181..3863579 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
INN77_RS19115 (3863579) 3863579..3863806 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
INN77_RS19120 (3863983) 3863983..3864234 + 252 WP_001540858.1 hypothetical protein -
INN77_RS19125 (3864509) 3864509..3865315 + 807 WP_010989071.1 DUF1460 domain-containing protein -
INN77_RS19135 (3865600) 3865600..3866358 - 759 WP_000244329.1 amidase activator ActS -
INN77_RS19140 (3866623) 3866623..3867168 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
INN77_RS19145 (3867244) 3867244..3868761 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3854735..3865315 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T233790 WP_000911336.1 NZ_CP091563:c3863579-3863181 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T233790 NZ_LN813019:c4247921-4247703 [Halomonas sp. R57-5]
GTGGGAGAGGCCGCGCATGCAAAGAGGCTTCGGCTTATTCTTGGTCAACTCAATGTAGCGTCAGATGCCAACGATATGGA
CTTGCCAGGTCTTCGCTTGCACGAACTCCCAGGTAAGCGCTCTGGAATCTGGTCAGTCACGGTTAGTGGTAACTGGCGCG
TGACGTTCCGGTTCGAGGACGTAGATGCCGAGATAGTGAATTACGAAGATTACCACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT233790 WP_000557549.1 NZ_CP091563:c3863806-3863579 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT233790 NZ_LN813019:c4247692-4247405 [Halomonas sp. R57-5]
ATGCTGATGCACAATCCTCCCCACCTTGGAGAAGTATTACGCGAGCTTTGCTTGGAGCCCCTTGGTCTTACTGTTACAGC
CGCTGTGGAAGCGCTCGGCGTAAGTCGCAAAACGCTCAGTGCTGTGCTGAACGGCAAGGCCGGTATTAGCCCTGAAATGG
CGGTGCGGCTTTCTATTGCGTTTGATACCTCTGCGGAAAGCTGGTTGAACCAGCAGTCCCAATACGAGCTTTGGCATGCC
GAACAGCATCGCAAAGAGCTTAAAGTAAAGAGGCTGGTTGCCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References