202568

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 850286..850911 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag BG493_RS04110 Protein ID WP_000911336.1
Coordinates 850513..850911 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag BG493_RS04105 Protein ID WP_000557549.1
Coordinates 850286..850513 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS04075 (845331) 845331..846848 + 1518 WP_000003339.1 lysine--tRNA ligase -
BG493_RS04080 (846924) 846924..847469 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
BG493_RS04085 (847734) 847734..848492 + 759 WP_000244329.1 amidase activator ActS -
BG493_RS04095 (848777) 848777..849583 - 807 WP_010989071.1 DUF1460 domain-containing protein -
BG493_RS04100 (849858) 849858..850109 - 252 WP_001540858.1 hypothetical protein -
BG493_RS04105 (850286) 850286..850513 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
BG493_RS04110 (850513) 850513..850911 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
BG493_RS04115 (851717) 851717..852253 + 537 WP_001038506.1 STM3031 family outer membrane protein -
BG493_RS04120 (852300) 852300..852932 + 633 WP_000835265.1 YfdX family protein -
BG493_RS04125 (853651) 853651..854235 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 848777..860102 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T202568 WP_000911336.1 NZ_CP074663:850513-850911 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T202568 NZ_CP099506:c1753726-1753517 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT202568 WP_000557549.1 NZ_CP074663:850286-850513 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT202568 NZ_CP099506:c1754031-1753738 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References