222022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3530247..3530872 Replicon chromosome
Accession NZ_CP085821
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF63_RS17285 Protein ID WP_000911336.1
Coordinates 3530247..3530645 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF63_RS17290 Protein ID WP_000557549.1
Coordinates 3530645..3530872 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF63_RS17270 (3526924) 3526924..3527505 - 582 WP_001244651.1 fimbrial protein -
LJF63_RS17275 (3528224) 3528224..3528856 - 633 WP_000835265.1 YfdX family protein -
LJF63_RS17280 (3528903) 3528903..3529439 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF63_RS17285 (3530247) 3530247..3530645 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF63_RS17290 (3530645) 3530645..3530872 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF63_RS17295 (3531081) 3531081..3531332 + 252 WP_001576352.1 hypothetical protein -
LJF63_RS17300 (3531612) 3531612..3532418 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF63_RS17310 (3532703) 3532703..3533461 - 759 WP_000244328.1 amidase activator ActS -
LJF63_RS17315 (3533726) 3533726..3534271 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF63_RS17320 (3534347) 3534347..3535864 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3521808..3532418 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T222022 WP_000911336.1 NZ_CP085821:c3530645-3530247 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T222022 NZ_CP117659:c233829-233527 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT222022 WP_000557549.1 NZ_CP085821:c3530872-3530645 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT222022 NZ_CP117659:c233455-233117 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAGTCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References