Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3652426..3653051 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag NL709_RS17835 Protein ID WP_000911336.1
Coordinates 3652426..3652824 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NL709_RS17840 Protein ID WP_000557549.1
Coordinates 3652824..3653051 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS17820 (3649103) 3649103..3649684 - 582 WP_001244651.1 fimbrial protein -
NL709_RS17825 (3650403) 3650403..3651035 - 633 WP_000835265.1 YfdX family protein -
NL709_RS17830 (3651082) 3651082..3651618 - 537 WP_001038502.1 STM3031 family outer membrane protein -
NL709_RS17835 (3652426) 3652426..3652824 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
NL709_RS17840 (3652824) 3652824..3653051 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL709_RS17845 (3653260) 3653260..3653511 + 252 WP_001576352.1 hypothetical protein -
NL709_RS17850 (3653791) 3653791..3654597 + 807 WP_001574939.1 DUF1460 domain-containing protein -
NL709_RS17860 (3654882) 3654882..3655640 - 759 WP_000244328.1 amidase activator ActS -
NL709_RS17865 (3655905) 3655905..3656450 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NL709_RS17870 (3656526) 3656526..3658043 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3643987..3654597 10610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T250933 WP_000911336.1 NZ_CP100666:c3652824-3652426 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT250933 WP_000557549.1 NZ_CP100666:c3653051-3652824 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References