Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 879086..879711 Replicon chromosome
Accession NZ_CP113541
Organism Salmonella enterica strain CHC

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag OXV05_RS04220 Protein ID WP_000911336.1
Coordinates 879313..879711 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag OXV05_RS04215 Protein ID WP_000557549.1
Coordinates 879086..879313 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OXV05_RS04185 (874131) 874131..875648 + 1518 WP_000003339.1 lysine--tRNA ligase -
OXV05_RS04190 (875724) 875724..876269 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
OXV05_RS04195 (876534) 876534..877292 + 759 WP_000244329.1 amidase activator ActS -
OXV05_RS04205 (877577) 877577..878383 - 807 WP_010989071.1 DUF1460 domain-containing protein -
OXV05_RS04210 (878658) 878658..878909 - 252 WP_001540858.1 hypothetical protein -
OXV05_RS04215 (879086) 879086..879313 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
OXV05_RS04220 (879313) 879313..879711 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
OXV05_RS04225 (880517) 880517..881053 + 537 WP_001038506.1 STM3031 family outer membrane protein -
OXV05_RS04230 (881100) 881100..881732 + 633 WP_000835265.1 YfdX family protein -
OXV05_RS04235 (882451) 882451..883035 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 877577..888902 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T266010 WP_000911336.1 NZ_CP113541:879313-879711 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT266010 WP_000557549.1 NZ_CP113541:879086-879313 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References