Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 681022..681647 Replicon chromosome
Accession NZ_CP047535
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10452

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag DXN08_RS03365 Protein ID WP_000911336.1
Coordinates 681249..681647 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag DXN08_RS03360 Protein ID WP_000557549.1
Coordinates 681022..681249 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN08_RS03330 (676067) 676067..677584 + 1518 WP_000003339.1 lysine--tRNA ligase -
DXN08_RS03335 (677660) 677660..678205 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
DXN08_RS03340 (678470) 678470..679228 + 759 WP_000244329.1 amidase activator ActS -
DXN08_RS03350 (679513) 679513..680319 - 807 WP_010989071.1 DUF1460 domain-containing protein -
DXN08_RS03355 (680594) 680594..680845 - 252 WP_001540858.1 hypothetical protein -
DXN08_RS03360 (681022) 681022..681249 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
DXN08_RS03365 (681249) 681249..681647 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
DXN08_RS03370 (682453) 682453..682989 + 537 WP_001038506.1 STM3031 family outer membrane protein -
DXN08_RS03375 (683036) 683036..683668 + 633 WP_000835265.1 YfdX family protein -
DXN08_RS03380 (684387) 684387..684971 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 679513..690838 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T146461 WP_000911336.1 NZ_CP047535:681249-681647 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T146461 NZ_CP062752:2648529-2648684 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT146461 WP_000557549.1 NZ_CP047535:681022-681249 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT146461 NZ_CP062752:c2648517-2648459 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References