226792

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 881044..881669 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LRM92_RS04310 Protein ID WP_000911336.1
Coordinates 881271..881669 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LRM92_RS04305 Protein ID WP_000557549.1
Coordinates 881044..881271 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS04275 (876089) 876089..877606 + 1518 WP_000003339.1 lysine--tRNA ligase -
LRM92_RS04280 (877682) 877682..878227 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LRM92_RS04285 (878492) 878492..879250 + 759 WP_000244329.1 amidase activator ActS -
LRM92_RS04295 (879535) 879535..880341 - 807 WP_010989071.1 DUF1460 domain-containing protein -
LRM92_RS04300 (880616) 880616..880867 - 252 WP_001540858.1 hypothetical protein -
LRM92_RS04305 (881044) 881044..881271 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LRM92_RS04310 (881271) 881271..881669 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LRM92_RS04315 (882475) 882475..883011 + 537 WP_001038506.1 STM3031 family outer membrane protein -
LRM92_RS04320 (883058) 883058..883690 + 633 WP_000835265.1 YfdX family protein -
LRM92_RS04325 (884409) 884409..884993 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 879535..890860 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T226792 WP_000911336.1 NZ_CP088138:881271-881669 [Salmonella enterica subsp. enterica serovar Hissar]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T226792 NZ_CP122629:c587477-587013 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT226792 WP_000557549.1 NZ_CP088138:881044-881271 [Salmonella enterica subsp. enterica serovar Hissar]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT226792 NZ_CP122629:c587812-587477 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References