Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 890987..891612 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag M9193_RS04295 Protein ID WP_000911336.1
Coordinates 891214..891612 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag M9193_RS04290 Protein ID WP_000557549.1
Coordinates 890987..891214 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS04260 (886032) 886032..887549 + 1518 WP_000003339.1 lysine--tRNA ligase -
M9193_RS04265 (887625) 887625..888170 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
M9193_RS04270 (888435) 888435..889193 + 759 WP_000244329.1 amidase activator ActS -
M9193_RS04280 (889478) 889478..890284 - 807 WP_010989071.1 DUF1460 domain-containing protein -
M9193_RS04285 (890559) 890559..890810 - 252 WP_001540858.1 hypothetical protein -
M9193_RS04290 (890987) 890987..891214 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
M9193_RS04295 (891214) 891214..891612 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
M9193_RS04300 (891992) 891992..892450 + 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
M9193_RS04305 (893130) 893130..893666 + 537 WP_001038506.1 STM3031 family outer membrane protein -
M9193_RS04310 (893713) 893713..894345 + 633 WP_000835265.1 YfdX family protein -
M9193_RS04315 (895064) 895064..895648 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 889478..901515 12037
flank IS/Tn - - 891992..892450 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T247620 WP_000911336.1 NZ_CP098438:891214-891612 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT247620 WP_000557549.1 NZ_CP098438:890987-891214 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References