Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 850163..850788 Replicon chromosome
Accession NZ_CP093386
Organism Salmonella enterica strain P048595

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag MOQ57_RS04100 Protein ID WP_000911336.1
Coordinates 850390..850788 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag MOQ57_RS04095 Protein ID WP_000557549.1
Coordinates 850163..850390 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ57_RS04065 (845208) 845208..846725 + 1518 WP_044815768.1 lysine--tRNA ligase -
MOQ57_RS04070 (846801) 846801..847346 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
MOQ57_RS04075 (847611) 847611..848369 + 759 WP_000244329.1 amidase activator ActS -
MOQ57_RS04085 (848654) 848654..849460 - 807 WP_010989071.1 DUF1460 domain-containing protein -
MOQ57_RS04090 (849735) 849735..849986 - 252 WP_001540858.1 hypothetical protein -
MOQ57_RS04095 (850163) 850163..850390 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
MOQ57_RS04100 (850390) 850390..850788 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
MOQ57_RS04105 (851594) 851594..852130 + 537 WP_001038506.1 STM3031 family outer membrane protein -
MOQ57_RS04110 (852177) 852177..852809 + 633 WP_000835265.1 YfdX family protein -
MOQ57_RS04115 (853528) 853528..854112 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 848654..859979 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T238352 WP_000911336.1 NZ_CP093386:850390-850788 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T238352 NZ_LR890318:c100924-100613 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT238352 WP_000557549.1 NZ_CP093386:850163-850390 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT238352 NZ_LR890318:c100616-100197 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References