221981

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 852311..852936 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF64_RS04055 Protein ID WP_000911336.1
Coordinates 852311..852709 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF64_RS04060 Protein ID WP_000557549.1
Coordinates 852709..852936 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF64_RS04040 (848987) 848987..849571 - 585 WP_001244638.1 fimbrial protein -
LJF64_RS04045 (850290) 850290..850922 - 633 WP_000835265.1 YfdX family protein -
LJF64_RS04050 (850969) 850969..851505 - 537 WP_001038506.1 STM3031 family outer membrane protein -
LJF64_RS04055 (852311) 852311..852709 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF64_RS04060 (852709) 852709..852936 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF64_RS04065 (853113) 853113..853364 + 252 WP_001540858.1 hypothetical protein -
LJF64_RS04070 (853639) 853639..854445 + 807 WP_010989071.1 DUF1460 domain-containing protein -
LJF64_RS04080 (854730) 854730..855488 - 759 WP_000244329.1 amidase activator ActS -
LJF64_RS04085 (855753) 855753..856298 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF64_RS04090 (856374) 856374..857891 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 843865..854445 10580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221981 WP_000911336.1 NZ_CP085820:c852709-852311 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221981 NZ_CP117647:4052284-4052625 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGATAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCAAAGAGAGCGAG
CTAATGCAGTCGCTGCGCCAGGTGTGCAAGCTTTCAGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAAAAAGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221981 WP_000557549.1 NZ_CP085820:c852936-852709 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221981 NZ_CP117647:c4052289-4052213 [Escherichia albertii]
AGTCATAACTGCTATTCCTTCGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2Y5V5

References