185725

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3133206..3133831 Replicon chromosome
Accession NZ_CP067091
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ER3625

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag JJB80_RS15225 Protein ID WP_000911336.1
Coordinates 3133206..3133604 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag JJB80_RS15230 Protein ID WP_000557549.1
Coordinates 3133604..3133831 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB80_RS15205 (3129170) 3129170..3129754 - 585 WP_001244638.1 fimbrial protein -
JJB80_RS15210 (3130473) 3130473..3131105 - 633 WP_000835265.1 YfdX family protein -
JJB80_RS15215 (3131152) 3131152..3131688 - 537 WP_001038506.1 STM3031 family outer membrane protein -
JJB80_RS15220 (3132368) 3132368..3132826 - 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
JJB80_RS15225 (3133206) 3133206..3133604 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
JJB80_RS15230 (3133604) 3133604..3133831 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
JJB80_RS15235 (3134008) 3134008..3134259 + 252 WP_001540858.1 hypothetical protein -
JJB80_RS15240 (3134534) 3134534..3135340 + 807 WP_010989071.1 DUF1460 domain-containing protein -
JJB80_RS15250 (3135625) 3135625..3136383 - 759 WP_000244329.1 amidase activator ActS -
JJB80_RS15255 (3136648) 3136648..3137193 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
JJB80_RS15260 (3137269) 3137269..3138786 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3124048..3135340 11292
flank IS/Tn - - 3132368..3132826 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T185725 WP_000911336.1 NZ_CP067091:c3133604-3133206 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T185725 NZ_CP089011:c230326-229883 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT185725 WP_000557549.1 NZ_CP067091:c3133831-3133604 [Salmonella enterica subsp. enterica serovar Typhimurium]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT185725 NZ_CP089011:c230553-230323 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References