Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 882341..882966 Replicon chromosome
Accession NZ_CP077668
Organism Salmonella enterica strain SP

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag KTP12_RS04305 Protein ID WP_000911336.1
Coordinates 882568..882966 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag KTP12_RS04300 Protein ID WP_000557549.1
Coordinates 882341..882568 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP12_RS04270 (877386) 877386..878903 + 1518 WP_000003339.1 lysine--tRNA ligase -
KTP12_RS04275 (878979) 878979..879524 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
KTP12_RS04280 (879789) 879789..880547 + 759 WP_000244329.1 amidase activator ActS -
KTP12_RS04290 (880832) 880832..881638 - 807 WP_010989071.1 DUF1460 domain-containing protein -
KTP12_RS04295 (881913) 881913..882164 - 252 WP_001540858.1 hypothetical protein -
KTP12_RS04300 (882341) 882341..882568 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
KTP12_RS04305 (882568) 882568..882966 + 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
KTP12_RS04310 (883772) 883772..884308 + 537 WP_001038506.1 STM3031 family outer membrane protein -
KTP12_RS04315 (884355) 884355..884987 + 633 WP_000835265.1 YfdX family protein -
KTP12_RS04320 (885706) 885706..886290 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 880832..892157 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T207381 WP_000911336.1 NZ_CP077668:882568-882966 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T207381 NZ_CP102972:c823662-823474 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT207381 WP_000557549.1 NZ_CP077668:882341-882568 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT207381 NZ_CP102972:c823951-823691 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References